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How to read a label: Hemp Seed Oil vs. CBD

The Importance of the Endocannabinoid System

Di Marzo, Vincenzo et al. “Endocannabinoid signalling and the deteriorating brain.” Nature reviews. Neuroscience vol. 16,1 (2015): 30-42. doi:10.1038/nrn3876

Katona, István, and Tamás F Freund. “Multiple functions of endocannabinoid signaling in the brain.” Annual review of neuroscience vol. 35 (2012): 529-58. doi:10.1146/annurev-neuro-062111-150420

Maccarrone, Mauro et al. “Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.” Nature reviews. Neuroscience vol. 15,12 (2014): 786-801. doi:10.1038/nrn3846

Zamberletti, Erica et al. “Lifelong imbalanced LA/ALA intake impairs emotional and cognitive behavior via changes in brain endocannabinoid system.” Journal of lipid research vol. 58,2 (2017): 301-316. doi:10.1194/jlr.M068387

Zou, Shenglong, and Ujendra Kumar. “Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.” International journal of molecular sciences vol. 19,3 833. 13 Mar. 2018, doi:10.3390/ijms19030833

What is Clinical Endocannabinoid Deficiency?

McPartland, John M et al. “Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system.” PloS one vol. 9,3 e89566. 12 Mar. 2014, doi:10.1371/journal.pone.0089566

Pisani V, Moschella V, Bari M, Fezza F, Galati S, et al. (2010) Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients. Movement Disorders 25: 920–924.

Russo, Ethan B. “Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.” Cannabis and cannabinoid research vol. 1,1 154-165. 1 Jul. 2016, doi:10.1089/can.2016.0009

Sleep + CBD

Brody, Jane. “Getting a Good Night's Sleep Without Drugs:

Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol. 1981;21(8–9 Suppl):417S–27S.

Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of Delta-9- tetrahydrocannabinol and cannabidiol on nocturnal sleep and earlymorning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305–13.

Shannon, Scott et al. “Cannabidiol in Anxiety and Sleep: A Large Case Series.” The Permanente journal vol. 23 (): 18-041. doi:10.7812/TPP/18-041

Vigil, Jacob M et al. “Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions.” Medicines (Basel, Switzerland) vol. 5,3 75. 11 Jul. 2018, doi:10.3390/medicines5030075

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